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Review Article| Volume 42, ISSUE 4, P593-603, December 2015

Therapeutic Options for Unscheduled Bleeding Associated with Long-Acting Reversible Contraception

Published:September 15, 2015DOI:https://doi.org/10.1016/j.ogc.2015.07.004

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      References

        • American College of Obstetricians and Gynecologists
        ACOG practice bulletin No. 121: long-acting reversible contraception: implants and intrauterine devices.
        Obstet Gynecol. 2011; 118: 184-196
        • Moreau C.
        • Cleland K.
        • Trussell J.
        Contraceptive discontinuation attributed to method dissatisfaction in the United States.
        Contraception. 2007; 76: 267-272
      1. Bayer Healthcare Pharmaceuticals Inc. Skyla prescribing information. 2013. Available at: http://labeling.bayerhealthcare.com/html/products/pi/Skyla_PI.pdf. Accessed August 17, 2015.

        • Sivin I.
        • Stern J.
        Health during prolonged use of levonorgestrel 20 micrograms/d and the copper TCu 380Ag intrauterine contraceptive devices: a multicenter study. International Committee for Contraception Research (ICCR).
        Fertil Steril. 1994; 61: 70-77
        • Casey P.M.
        • Long M.E.
        • Marnach M.L.
        • et al.
        Bleeding related to etonogestrel subdermal implant in a US population.
        Contraception. 2011; 83: 426-430
        • Mansour D.
        • Korver T.
        • Marintcheva-Petrova M.
        • et al.
        The effects of Implanon on menstrual bleeding patterns.
        Eur J Contracept Reprod Health Care. 2008; 13: 13-28
        • Makarainen L.
        • Ylikorkala O.
        Ibuprofen prevents IUCD-induced increases in menstrual blood loss.
        Br J Obstet Gynaecol. 1986; 93: 285-288
        • Suvisaari J.
        • Lahteenmaki P.
        Detailed analysis of menstrual bleeding patterns after postmenstrual and postabortal insertion of a copper IUD or a levonorgestrel-releasing intrauterine system.
        Contraception. 1996; 54: 201-208
        • Champion C.B.
        • Behlilovic B.
        • Arosemena J.M.
        • et al.
        A three-year evaluation of TCu 380 Ag and multiload Cu 375 intrauterine devices.
        Contraception. 1988; 38: 631-639
        • Roy S.
        • Shaw Jr., S.T.
        Role of prostaglandins in IUD-associated uterine bleeding–effect of a prostaglandin synthetase inhibitor (ibuprofen).
        Obstet Gynecol. 1981; 58: 101-106
        • Toppozada M.
        Treatment of increased menstrual blood loss in IUD users.
        Contraception. 1987; 36: 145-157
        • Wu S.
        • Wang C.
        • Cheng W.
        • et al.
        Randomized multi-center study of baofuxin for treatment of bleeding side-effect induced by IUD.
        Reprod Contracept. 2000; 11: 152-157
        • Pizarro E.
        • Mehech G.
        • Hidalgo M.
        • et al.
        Effect of meclofenamic acid on menstruation in hypermenorrheic women using intrauterine devices.
        Rev Chil Obstet Ginecol. 1988; 53 ([in Spanish]): 43-56
        • Mercorio F.
        • De Simone R.
        • Di Carlo C.
        • et al.
        Effectiveness and mechanism of action of desmopressin in the treatment of copper intrauterine device-related menorrhagia: a pilot study.
        Hum Reprod. 2003; 18: 2319-2322
        • Ylikorkala O.
        • Viinikka L.
        Comparison between antifibrinolytic and antiprostaglandin treatment in the reduction of increased menstrual blood loss in women with intrauterine contraceptive devices.
        Br J Obstet Gynaecol. 1983; 90: 78-83
        • Pedron N.
        • Lozano M.
        • Gallegos A.J.
        The effect of acetylsalicylic acid on menstrual blood loss in women with IUDs.
        Contraception. 1987; 36: 295-303
        • Lin X.
        • Gao E.S.
        • Li D.
        • et al.
        Preventive treatment of intrauterine device-induced menstrual blood loss with tranexamic acid in Chinese women.
        Acta Obstet Gynecol Scand. 2007; 86: 1126-1129
        • Hidalgo M.
        • Bahamondes L.
        • Perrotti M.
        • et al.
        Bleeding patterns and clinical performance of the levonorgestrel-releasing intrauterine system (Mirena) up to two years.
        Contraception. 2002; 65: 129-132
        • Madden T.
        • Proehl S.
        • Allsworth J.E.
        • et al.
        Naproxen or estradiol for bleeding and spotting with the levonorgestrel intrauterine system: a randomized controlled trial.
        Am J Obstet Gynecol. 2012; 206: e1-e8
        • Sordal T.
        • Inki P.
        • Draeby J.
        • et al.
        Management of initial bleeding or spotting after levonorgestrel-releasing intrauterine system placement: a randomized controlled trial.
        Obstet Gynecol. 2013; 121: 934-941
        • Lal S.
        • Kriplani A.
        • Kulshrestha V.
        • et al.
        Efficacy of mifepristone in reducing intermenstrual vaginal bleeding in users of the levonorgestrel intrauterine system.
        Int J Gynaecol Obstet. 2010; 109: 128-130
        • Warner P.
        • Guttinger A.
        • Glasier A.F.
        • et al.
        Randomized placebo-controlled trial of CDB-2914 in new users of a levonorgestrel-releasing intrauterine system shows only short-lived amelioration of unscheduled bleeding.
        Hum Reprod. 2010; 25: 345-353
        • Darney P.
        • Patel A.
        • Rosen K.
        • et al.
        Safety and efficacy of a single-rod etonogestrel implant (Implanon): results from 11 international clinical trials.
        Fertil Steril. 2009; 91: 1646-1653
        • Zheng S.R.
        • Zheng H.M.
        • Qian S.Z.
        • et al.
        A randomized multicenter study comparing the efficacy and bleeding pattern of a single-rod (Implanon) and a six-capsule (Norplant) hormonal contraceptive implant.
        Contraception. 1999; 60: 1-8
        • Division of Reproductive Health
        • National Center for Chronic Disease Prevention and Health Promotion
        • Centers for Disease Control and Prevention (CDC)
        U.S. selected practice recommendations for contraceptive use, 2013: adapted from the World Health Organization selected practice recommendations for contraceptive use, 2nd edition.
        MMWR Recomm Rep. 2013; 62: 1-60
        • Mansour D.
        • Bahamondes L.
        • Critchley H.
        • et al.
        The management of unacceptable bleeding patterns in etonogestrel-releasing contraceptive implant users.
        Contraception. 2011; 83: 202-210
        • Phupong V.
        • Sophonsritsuk A.
        • Taneepanichskul S.
        The effect of tranexamic acid for treatment of irregular uterine bleeding secondary to Norplant use.
        Contraception. 2006; 73: 253-256
        • Casey P.M.
        • Long M.E.
        • Drozdowicz L.B.
        • et al.
        Management of etonogestrel subdermal implant-related bleeding.
        J Reprod Med. 2014; 59: 306-312
        • Phaliwong P.
        • Taneepanichskul S.
        The effect of mefenamic acid on controlling irregular uterine bleeding second to Implanon use.
        J Med Assoc Thai. 2004; 87: S64-S68
        • Weisberg E.
        • Hickey M.
        • Palmer D.
        • et al.
        A pilot study to assess the effect of three short-term treatments on frequent and/or prolonged bleeding compared to placebo in women using Implanon.
        Hum Reprod. 2006; 21: 295-302
        • Weisberg E.
        • Hickey M.
        • Palmer D.
        • et al.
        A randomized controlled trial of treatment options for troublesome uterine bleeding in Implanon users.
        Hum Reprod. 2009; 24: 1852-1861