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Review Article| Volume 47, ISSUE 1, P1-15, March 2020

Social Determinants of Placental Health and Future Disease Risks for Babies

  • Kent L. Thornburg
    Correspondence
    Corresponding author. Knight Cardiovascular Institute, School of Medicine, Oregon Health & Science University, 3030 SW Moody Avenue, MDYMI, Portland, OR 97239.
    Affiliations
    Moore Institute, Oregon Health & Science University, 3030 SW Moody Avenue, MDYMI, Portland, OR 97239, USA

    Center for Developmental Health, Knight Cardiovascular Institute, Oregon Health & Science University, 3030 SW Moody Avenue, MDYMI, Portland, OR 97239, USA

    Department of Obstetrics and Gynecology, Oregon Health & Science University, 3181 SW Sam Jackson Road, Portland, OR 97239, USA

    Bob and Charlee Moore Institute for Nutrition & Wellness, School of Medicine, Oregon Health & Science University, 3030 SW Moody Avenue, MDYMI, Portland, OR 97239, USA
    Search for articles by this author
  • Janne Boone-Heinonen
    Affiliations
    School of Public Health, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Search for articles by this author
  • Amy M. Valent
    Affiliations
    Department of Obstetrics and Gynecology, Oregon Health & Science University, 3181 SW Sam Jackson Road, Portland, OR 97239, USA
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      References

        • Wills A.K.
        • Chinchwadkar M.C.
        • Joglekar C.V.
        • et al.
        Maternal and paternal height and BMI and patterns of fetal growth: the Pune Maternal Nutrition Study.
        Early Hum Dev. 2010; 86: 535-540
        • Sferruzzi-Perri A.N.
        • Camm E.J.
        The programming power of the placenta.
        Front Physiol. 2016; 7: 33
        • Burton G.J.
        • Fowden A.L.
        • Thornburg K.L.
        Placental origins of chronic disease.
        Physiol Rev. 2016; 96: 1509-1565
        • Barker D.J.
        • Winter P.D.
        • Osmond C.
        • et al.
        Weight in infancy and death from ischaemic heart disease.
        Lancet. 1989; 2: 577-580
        • Roseboom T.
        • van der Meulen J.
        • Ravelli A.
        • et al.
        Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview.
        Mol Cell Endocrinol. 2001; 185: 93-98
        • Barker D.J.
        • Thornburg K.L.
        Placental programming of chronic diseases, cancer and lifespan: a review.
        Placenta. 2013; 34: 841-845
        • Eriksson J.G.
        • Kajantie E.
        • Thornburg K.L.
        • et al.
        Mother's body size and placental size predict coronary heart disease in men.
        Eur Heart J. 2011; 32: 2297-2303
        • Barker D.J.
        • Thornburg K.L.
        • Osmond C.
        • et al.
        The surface area of the placenta and hypertension in the offspring in later life.
        Int J Dev Biol. 2010; 54: 525-530
        • Eriksson J.G.
        • Kajantie E.
        • Osmond C.
        • et al.
        Boys live dangerously in the womb.
        Am J Hum Biol. 2010; 22: 330-335
        • Boyle J.P.
        • Honeycutt A.A.
        • Narayan K.M.
        • et al.
        Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the U.S.
        Diabetes care. 2001; 24: 1936-1940
        • Benjamin E.J.
        • Virani S.S.
        • Callaway C.W.
        • et al.
        Heart disease and stroke statistics-2018 update: a report from the American Heart Association.
        Circulation. 2018; 137: e67-e492
        • Arora S.
        • Stouffer G.A.
        • Kucharska-Newton A.M.
        • et al.
        Twenty year trends and sex differences in young adults hospitalized with acute myocardial infarction.
        Circulation. 2019; 139: 1047-1056
      1. More than 100 million Americans have diabetes or prediabetes. Centers for Disease Control and Prevention Press Release, 2017 (Available at: https://www.cdc.gov/media/releases/2017/p0718-diabetes-report.html)
      2. Cardiovascular Disease and Diabetes American Heart Association Center for Health Metrics and Evaluation, 2015. This is a website report by the American Heart Association. https://www.heart.org/en/health-topics/diabetes/why-diabetes-matters/cardiovascular-disease--diabetes.

        • Health and Economic Costs of Chronic Disease
        National Center for Chronic Disease Prevention and Health Promotion.
        (Available at:)
      3. Cardiovascular disease: a costly burden for America, projections through 2035. American Heart Association Center for Health Metrics and Evaluation, 2017 (Available at:)
      4. National health expenditure fact sheet. Centers for Medicare & Medicaid Services, 2019 (Available at:)
        • Doyle S.K.
        • Chang A.M.
        • Levy P.
        • et al.
        Achieving health equity in hypertension management through addressing the social determinants of health.
        Curr Hypertens Rep. 2019; 21: 58
        • Braveman P.
        • Gottlieb L.
        The social determinants of health: it's time to consider the causes of the causes.
        Public Health Rep. 2014; 129: 19-31
        • Braveman P.
        • Egerter S.
        • Williams D.R.
        The social determinants of health: coming of age.
        Annu Rev Public Health. 2011; 32: 381-398
        • Adler N.E.
        • Stead W.W.
        Patients in context--EHR capture of social and behavioral determinants of health.
        N Engl J Med. 2015; 372: 698-701
        • Institute of Medicine
        Capturing social and behavioral domains in electronic health records: phase 1.
        The National Academic Press, Washington, DC2014
        • National Academies of Sciences, Engineering, and Medicine
        A framework for educating health professionals to address the social determinants of health.
        National Academies Press (US), Washington (DC)2016
      5. Social Determinants of Health. Office of disease prevention and health promotion, Healthy Peoplegov. 2019;2020 Topics & Objectives.
        (Available at:)
        • Dwyer-Lindgren L.
        • Bertozzi-Villa A.
        • Stubbs R.W.
        • et al.
        Inequalities in life expectancy among US counties, 1980 to 2014: temporal trends and key drivers.
        JAMA Intern Med. 2017; 177: 1003-1011
        • Achenbach J.
        U.S. life expectancy varies by more than 20 years from county to county.
        Washington Post May 9,. 2017;
      6. Mapping life expectancy: 16 years in Chicago, Illinois. Center on Society and Health, Virginia Commonwealth University, 2019 (Available at:)
        • Messer L.C.
        • Boone-Heinonen J.
        • Mponwane L.
        • et al.
        Developmental programming: priming disease susceptibility for subsequent generations.
        Curr Epidemiol Rep. 2015; 2: 37-51
        • Wheeler S.M.
        • Bryant A.S.
        Racial and ethnic disparities in health and health care.
        Obstet Gynecol Clin North Am. 2017; 44: 1-11
        • Dodson R.E.
        • Udesky J.O.
        • Colton M.D.
        • et al.
        Chemical exposures in recently renovated low-income housing: influence of building materials and occupant activities.
        Environ Int. 2017; 109: 114-127
        • Gross R.S.
        • Mendelsohn A.L.
        • Arana M.M.
        • et al.
        Food insecurity during pregnancy and breastfeeding by low-income hispanic mothers.
        Pediatrics. 2019; 143 ([pii:e20184113])
        • Leung C.W.
        • Epel E.S.
        • Ritchie L.D.
        • et al.
        Food insecurity is inversely associated with diet quality of lower-income adults.
        J Acad Nutr Diet. 2014; 114: 1943-1953.e2
        • Holmes L.M.
        • Ling P.M.
        Workplace secondhand smoke exposure: a lingering hazard for young adults in California.
        Tob Control. 2017; 26: e79-e84
        • Moyce S.C.
        • Schenker M.
        Occupational exposures and health outcomes among immigrants in the USA.
        Curr Environ Health Rep. 2017; 4: 349-354
        • Harris K.M.
        Mapping inequality: childhood asthma and environmental injustice, a case study of St. Louis, Missouri.
        Soc Sci Med. 2019; 230: 91-110
        • Payne-Sturges D.
        • Gee G.C.
        National environmental health measures for minority and low-income populations: tracking social disparities in environmental health.
        Environ Res. 2006; 102: 154-171
        • Yu H.
        • Stuart A.L.
        Exposure and inequality for select urban air pollutants in the Tampa Bay area.
        Sci Total Environ. 2016; 551-552: 474-483
        • Holliday C.N.
        • McCauley H.L.
        • Silverman J.G.
        • et al.
        Racial/ethnic differences in women's experiences of reproductive coercion, intimate partner violence, and unintended pregnancy.
        J Womens Health (Larchmt). 2017; 26: 828-835
        • Sumner S.A.
        • Mercy J.A.
        • Dahlberg L.L.
        • et al.
        Violence in the United States: status, challenges, and opportunities.
        JAMA. 2015; 314: 478-488
        • Panza G.A.
        • Puhl R.M.
        • Taylor B.A.
        • et al.
        Links between discrimination and cardiovascular health among socially stigmatized groups: a systematic review.
        PLoS One. 2019; 14: e0217623
        • Cuevas A.G.
        • Ho T.
        • Rodgers J.
        • et al.
        Developmental timing of initial racial discrimination exposure is associated with cardiovascular health conditions in adulthood.
        Ethn Health. 2019; ([Epub ahead of print])
        • Dominguez T.P.
        Race, racism, and racial disparities in adverse birth outcomes.
        Clin Obstet Gynecol. 2008; 51: 360-370
        • Clarke J.G.
        • Adashi E.Y.
        Perinatal care for incarcerated patients: a 25-year-old woman pregnant in jail.
        JAMA. 2011; 305: 923-929
        • Sufrin C.
        • Kolbi-Molinas A.
        • Roth R.
        Reproductive justice, health disparities and incarcerated women in the United States.
        Perspect Sex Reprod Health. 2015; 47: 213-219
        • Chisholm C.A.
        • Bullock L.
        • Ferguson 2nd, J.E.J.
        Intimate partner violence and pregnancy: epidemiology and impact.
        Am J Obstet Gynecol. 2017; 217: 141-144
        • Hertzman C.
        • Boyce T.
        How experience gets under the skin to create gradients in developmental health.
        Annu Rev Public Health. 2010; 31 (323p following 347): 329-347
        • McEwen B.S.
        Brain on stress: how the social environment gets under the skin.
        Proc Natl Acad Sci U S A. 2012; 109: 17180-17185
        • Laraia B.A.
        • Leak T.M.
        • Tester J.M.
        • et al.
        Biobehavioral factors that shape nutrition in low-income populations: a narrative review.
        Am J Prev Med. 2017; 52: S118-S126
        • Kim M.K.
        • Lee S.M.
        • Bae S.H.
        • et al.
        Socioeconomic status can affect pregnancy outcomes and complications, even with a universal healthcare system.
        Int J Equity Health. 2018; 17: 2
        • Leppalahti S.
        • Gissler M.
        • Mentula M.
        • et al.
        Is teenage pregnancy an obstetric risk in a welfare society? A population-based study in Finland, from 2006 to 2011.
        BMJ open. 2013; 3: e003225
        • Bo S.
        • Menato G.
        • Bardelli C.
        • et al.
        Low socioeconomic status as a risk factor for gestational diabetes.
        Diabetes Metab. 2002; 28: 139-140
        • Mulia N.
        • Schmidt L.
        • Bond J.
        • et al.
        Stress, social support and problem drinking among women in poverty.
        Addiction. 2008; 103: 1283-1293
        • Atif N.
        • Lovell K.
        • Rahman A.
        Maternal mental health: the missing "m" in the global maternal and child health agenda.
        Semin Perinatol. 2015; 39: 345-352
        • Osterman M.J.K.
        • Martin J.A.
        Timing and adequacy of prenatal care in the United States, 2016.
        Natl Vital Stat Rep. 2018; 67: 1-14
        • Barker D.J.
        • Larsen G.
        • Osmond C.
        • et al.
        The placental origins of sudden cardiac death.
        Int J Epidemiol. 2012; 41: 1394-1399
        • Barker D.J.
        • Osmond C.
        • Thornburg K.L.
        • et al.
        The lifespan of men and the shape of their placental surface at birth.
        Placenta. 2011; 32: 783-787
        • Dimasuay K.G.
        • Boeuf P.
        • Powell T.L.
        • et al.
        Placental responses to changes in the maternal environment determine fetal growth.
        Front Physiol. 2016; 7: 12
        • Howell K.R.
        • Powell T.L.
        Effects of maternal obesity on placental function and fetal development.
        Reproduction. 2017; 153: R97-R108
        • Hiilamo A.
        • Lallukka T.
        • Manty M.
        • et al.
        Obesity and socioeconomic disadvantage in midlife female public sector employees: a cohort study.
        BMC Public Health. 2017; 17: 842
        • Williams D.R.
        • Collins C.
        Racial residential segregation: a fundamental cause of racial disparities in health.
        Public Health Rep. 2001; 116: 404-416
        • Chae D.H.
        • Clouston S.
        • Martz C.D.
        • et al.
        Area racism and birth outcomes among Blacks in the United States.
        Soc Sci Med. 2018; 199: 49-55
        • Bower K.M.
        • Geller R.J.
        • Perrin N.A.
        • et al.
        Experiences of racism and preterm birth: findings from a pregnancy risk assessment monitoring system, 2004 through 2012.
        Womens Health Issues. 2018; 28: 495-501
        • McKinnon B.
        • Yang S.
        • Kramer M.S.
        • et al.
        Comparison of black-white disparities in preterm birth between Canada and the United States.
        CMAJ. 2016; 188: E19-E26
        • Hilmert C.J.
        • Dominguez T.P.
        • Schetter C.D.
        • et al.
        Lifetime racism and blood pressure changes during pregnancy: implications for fetal growth.
        Health Psychol. 2014; 33: 43-51
        • Pantham P.
        • Aye I.L.
        • Powell T.L.
        Inflammation in maternal obesity and gestational diabetes mellitus.
        Placenta. 2015; 36: 709-715
        • Myatt L.
        Role of placenta in preeclampsia.
        Endocrine. 2002; 19: 103-111
        • Roberts J.M.
        • Escudero C.
        The placenta in preeclampsia.
        Pregnancy Hypertens. 2012; 2: 72-83
        • Ursini G.
        • Punzi G.
        • Chen Q.
        • et al.
        Convergence of placenta biology and genetic risk for schizophrenia.
        Nat Med. 2018; 24: 792-801
        • Tan J.
        • McKenzie C.
        • Potamitis M.
        • et al.
        The role of short-chain fatty acids in health and disease.
        Adv Immunol. 2014; 121: 91-119
        • Walker R.W.
        • Clemente J.C.
        • Peter I.
        • et al.
        The prenatal gut microbiome: are we colonized with bacteria in utero?.
        Pediatr Obes. 2017; 12: 3-17
        • Yu K.
        • Rodriguez M.D.
        • Paul Z.
        • et al.
        Proof of principle: physiological transfer of small numbers of bacteria from mother to fetus in late-gestation pregnant sheep.
        PLoS One. 2019; 14: e0217211
        • Cui B.
        • Gai Z.
        • She X.
        • et al.
        Effects of chronic noise on glucose metabolism and gut microbiota-host inflammatory homeostasis in rats.
        Sci Rep. 2016; 6: 36693
        • Hemmings S.M.J.
        • Malan-Muller S.
        • van den Heuvel L.L.
        • et al.
        The microbiome in posttraumatic stress disorder and trauma-exposed controls: an exploratory study.
        Psychosom Med. 2017; 79: 936-946
        • Stenvinkel P.
        • Jani A.H.
        • Johnson R.J.
        Hibernating bears (Ursidae): metabolic magicians of definite interest for the nephrologist.
        Kidney Int. 2013; 83: 207-212
        • Nelson R.A.
        • Jones J.D.
        • Wahner H.W.
        • et al.
        Nitrogen metabolism in bears: urea metabolism in summer starvation and in winter sleep and role of urinary bladder in water and nitrogen conservation.
        Mayo Clin Proc. 1975; 50: 141-146
        • Nelson R.A.
        Protein and fat metabolism in hibernating bears.
        Fed Proc. 1980; 39: 2955-2958
        • Potdar R.D.
        • Sahariah S.A.
        • Gandhi M.
        • et al.
        Improving women's diet quality preconceptionally and during gestation: effects on birth weight and prevalence of low birth weight--a randomized controlled efficacy trial in India (Mumbai Maternal Nutrition Project).
        Am J Clin Nutr. 2014; 100: 1257-1268
        • Briefel R.R.
        • Johnson C.L.
        Secular trends in dietary intake in the United States.
        Annu Rev Nutr. 2004; 24: 401-431
        • Ryu S.
        • Shivappa N.
        • Veronese N.
        • et al.
        Secular trends in Dietary Inflammatory Index among adults in the United States, 1999-2014.
        Eur J Clin Nutr. 2019; 73: 1343-1351
        • Rondo P.H.
        • Ferreira R.F.
        • Nogueira F.
        • et al.
        Maternal psychological stress and distress as predictors of low birth weight, prematurity and intrauterine growth retardation.
        Eur J Clin Nutr. 2003; 57: 266-272
        • Wadhwa P.D.
        • Sandman C.A.
        • Garite T.J.
        The neurobiology of stress in human pregnancy: implications for prematurity and development of the fetal central nervous system.
        Prog Brain Res. 2001; 133: 131-142
        • King S.
        • Dancause K.
        • Turcotte-Tremblay A.M.
        • et al.
        Using natural disasters to study the effects of prenatal maternal stress on child health and development.
        Birth Defects Res C Embryo Today. 2012; 96: 273-288
        • King S.
        • Laplante D.P.
        The effects of prenatal maternal stress on children's cognitive development: project Ice Storm.
        Stress. 2005; 8: 35-45
        • Dancause K.N.
        • Laplante D.P.
        • Hart K.J.
        • et al.
        Prenatal stress due to a natural disaster predicts adiposity in childhood: the Iowa Flood Study.
        J Obes. 2015; 2015: 570541
        • Eskenazi B.
        • Marks A.R.
        • Catalano R.
        • et al.
        Low birthweight in New York City and upstate New York following the events of September 11th.
        Hum Reprod. 2007; 22: 3013-3020
        • Nesari M.
        • Olson J.K.
        • Vandermeer B.
        • et al.
        Does a maternal history of abuse before pregnancy affect pregnancy outcomes? A systematic review with meta-analysis.
        BMC Pregnancy Childbirth. 2018; 18: 404
        • Petraglia F.
        • Imperatore A.
        • Challis J.R.
        Neuroendocrine mechanisms in pregnancy and parturition.
        Endocr Rev. 2010; 31: 783-816
        • Weinstock M.
        The potential influence of maternal stress hormones on development and mental health of the offspring.
        Brain Behav Immun. 2005; 19: 296-308
        • Tyrrell J.
        • Melzer D.
        • Henley W.
        • et al.
        Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010.
        Environ Int. 2013; 59: 328-335
        • Anand M.
        • Agarwal P.
        • Singh L.
        • et al.
        Persistent organochlorine pesticides and oxidant/antioxidant status in the placental tissue of the women with full-term and pre-term deliveries.
        Toxicol Res. 2015; 4: 326-332
        • Chen Z.
        • Myers R.
        • Wei T.
        • et al.
        Placental transfer and concentrations of cadmium, mercury, lead, and selenium in mothers, newborns, and young children.
        J Expo Sci Environ Epidemiol. 2014; 24: 537-544
        • Ahamed M.
        • Mehrotra P.K.
        • Kumar P.
        • et al.
        Placental lead-induced oxidative stress and preterm delivery.
        Environ Toxicol Pharmacol. 2009; 27: 70-74
        • Manikkam M.
        • Tracey R.
        • Guerrero-Bosagna C.
        • et al.
        Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations.
        PLoS One. 2013; 8: e55387
        • Devault A.
        • Gros P.
        Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.
        Mol Cell Biol. 1990; 10: 1652-1663
        • Sun M.
        • Kingdom J.
        • Baczyk D.
        • et al.
        Expression of the multidrug resistance P-glycoprotein, (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation.
        Placenta. 2006; 27: 602-609
        • Goralski K.B.
        • Hartmann G.
        • Piquette-Miller M.
        • et al.
        Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin.
        Br J Pharmacol. 2003; 139: 35-48
        • Sukhai M.
        • Yong A.
        • Pak A.
        • et al.
        Decreased expression of P-glycoprotein in interleukin-1beta and interleukin-6 treated rat hepatocytes.
        Inflamm Res. 2001; 50: 362-370
        • Duan H.
        • Zhou K.
        • Zhang Y.
        • et al.
        HDAC2 was involved in placental P-glycoprotein regulation both in vitro and vivo.
        Placenta. 2017; 58: 105-114
        • Yates C.R.
        • Chang C.
        • Kearbey J.D.
        • et al.
        Structural determinants of P-glycoprotein-mediated transport of glucocorticoids.
        Pharm Res. 2003; 20: 1794-1803
        • Benediktsson R.
        • Calder A.A.
        • Edwards C.R.
        • et al.
        Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure.
        Clin Endocrinol. 1997; 46: 161-166