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References
- Association of gestational weight gain with maternal and infant outcomes: a systematic review and meta-analysis.JAMA. 2017; 317: 2207-2225
- Effect of in utero and early-life conditions on adult health and disease.N Engl J Med. 2008; 359: 61-73
- Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years.BMJ. 2013; 347: f4539
- The short- and long-term implications of maternal obesity on the mother and her offspring.BJOG. 2006; 113: 1126-1133
- The developmental origins of adult disease.Matern Child Nutr. 2005; 1: 130-141
- The neonatal implications of a high placental ratio in small-for-gestational age infants.Placenta. 1999; 20: 723-726
- Clinical significance of absent or reversed end diastolic velocity waveforms in umbilical artery.Lancet. 1994; 344: 1664-1668
- Regulation of placental amino acid transport and fetal growth.Prog Mol Biol Transl Sci. 2017; 145: 217-251
- Role of placental nutrient sensing in developmental programming.Clin Obstet Gynecol. 2013; 56: 591-601
- Development of the human placenta.Development. 2019; 146: dev163428
- Regulation of placental extravillous trophoblasts by the maternal uterine environment.Front Immunol. 2018; 9: 2597
- Fine structure of the paracellular junctions of terminal villous capillaries in the perfused human placenta.Cell Tissue Res. 1992; 268: 447-452
- Have we neglected the role of fetal endothelium in transplacental transport?.Traffic. 2014; 15: 122-126
- The placenta: a multifaceted, transient organ.Philos Trans R Soc Lond B Biol Sci. 2015; 370: 20140066
- Insulin stimulates GLUT4 trafficking to the syncytiotrophoblast basal plasma membrane in the human placenta.J Clin Endocrinol Metab. 2019; 104: 4225-4238
- Spatial polarization of insulin-like growth factor receptors on the human syncytiotrophoblast.Pediatr Res. 1997; 41: 258-265
- Review: adiponectin--the missing link between maternal adiposity, placental transport and fetal growth?.Placenta. 2013; 34: S40-S45
- Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal development.Birth Defects Res B Dev Reprod Toxicol. 2010; 89: 339-349
- Regulation of placental amino acid transporter activity by mammalian target of rapamycin.Am J Physiol Cell Physiol. 2009; 296: C142-C150
- Gestational age-dependent expression of insulin-like growth factor-binding protein-1 (IGFBP-1) phosphoisoforms in human extraembryonic cavities, maternal serum, and decidua suggests decidua as the primary source of IGFBP-1 in these fluids during early pregnancy.J Clin Endocrinol Metab. 1997; 82: 1894-1898
- Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR.Biochim Biophys Acta Mol Basis Dis. 2020; 1866: 165373
- Maternal serum concentrations of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to maternal body weight and composition and infant birth weight.Br J Nutr. 2010; 104: 842-848
- IUGR is associated with marked hyperphosphorylation of decidual and maternal plasma IGFBP-1.J Clin Endocrinol Metab. 2019; 104: 408-422
- Increased insulin-like growth factor binding protein-1 phosphorylation in decidualized stromal mesenchymal cells in human intrauterine growth restriction placentas.J Histochem Cytochem. 2018; 66: 617-630
- Study of genetic expression of intrauterine growth factors IGF-I and EGFR in placental tissue from pregnancies with intrauterine growth retardation.J Pediatr Endocrinol Metab. 2004; 17: 445-450
- Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling.Endocrinology. 2005; 146: 1498-1505
- Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.Am J Pathol. 2008; 173: 451-462
- Impairment of insulin receptor signal transduction in placentas of intra-uterine growth-restricted newborns and its relationship with fetal growth.Eur J Endocrinol. 2011; 164: 45-52
- Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies.J Clin Endocrinol Metab. 2013; 98: 105-113
- Increased placental IGF-1/mTOR activity in macrosomia born to women with gestational diabetes.Diabetes Res Clin Pract. 2018; 146: 211-219
- Maternal hormones linking maternal body mass index and dietary intake to birth weight.Am J Clin Nutr. 2008; 87: 1743-1749
- mTOR signaling in growth, metabolism, and disease.Cell. 2017; 168: 960-976
- Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells.J Physiol. 2013; 591: 609-625
- mTOR folate sensing links folate availability to trophoblast cell function.J Physiol. 2017; 595: 4189-4206
- Mechanistic target of rapamycin complex 1 promotes the expression of genes encoding electron transport chain proteins and stimulates oxidative phosphorylation in primary human trophoblast cells by regulating mitochondrial biogenesis.Sci Rep. 2019; 9: 246
- Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth.J Physiol. 2007; 582: 449-459
- Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR.Clin Sci (Lond). 2015; 129: 1131-1141
- Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters.Endocrinology. 2011; 152: 1119-1129
- Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon.FASEB J. 2014; 28: 1294-1305
- Expression of mammalian target of rapamycin and downstream targets in normal and gestational diabetic human term placenta.Reprod Sci. 2016; 23: 324-332
- Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth.Proc Natl Acad Sci U S A. 2015; 112: 12858-12863
- Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth.Am J Physiol Regul Integr Comp Physiol. 2016; 310: R87-R93
- Novel roles of mechanistic target of rapamycin signaling in regulating fetal growth.Biol Reprod. 2019; 100: 872-884
- The role of AMP-activated protein kinase in obesity.Front Horm Res. 2008; 36: 198-211
- Relationship of adiponectin and resistin levels in umbilical serum, maternal serum and placenta with neonatal birth weight.Aust N Z J Obstet Gynaecol. 2010; 50: 432-438
- Patterns of adiponectin expression in term pregnancy: impact of obesity.J Clin Endocrinol Metab. 2014; 99: 3427-3434
- The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia.Am J Obstet Gynecol. 2005; 193: 979-983
- Maternal adipokines and insulin as biomarkers of pregnancies complicated by overweight and obesity.Diabetol Metab Syndr. 2016; 8: 68
- Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.Nature. 2003; 423: 762-769
- Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha.Diabetes. 2006; 55: 2562-2570
- Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells.Diabetes. 2010; 59: 1161-1170
- Adiponectin inhibits insulin function in primary trophoblasts by PPARalpha-mediated ceramide synthesis.Mol Endocrinol. 2014; 28: 512-524
- Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring.Int J Obes (Lond). 2020; 44: 488-499
- Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring.FASEB J. 2019; 33: 2899-2909
- Inflammation in maternal obesity and gestational diabetes mellitus.Placenta. 2015; 36: 709-715
- Maternal obesity and the uterine immune cell landscape: the shaping role of inflammation.Int J Mol Sci. 2020; 21: 3776
- Molecular pathways disrupted by gestational diabetes mellitus.J Mol Endocrinol. 2019; 63: R51-R72
- Cross-talk between oxidative stress and inflammation in preeclampsia.Oxid Med Cell Longev. 2019; 2019: 8238727
- The placenta cytokine network and inflammatory signals.Placenta. 2006; 27: 794-798
- Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways.Biol Reprod. 2014; 90: 129
- Placental function in maternal obesity.Clin Sci (Lond). 2020; 134: 961-984
- IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2.Am J Physiol Cell Physiol. 2009; 297: C1228-C1235
- TNF-alpha stimulates system A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signaling.Physiol Rep. 2015; 3: e12594
- Interleukin-1beta inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts.Mol Cell Endocrinol. 2013; 381: 46-55
- Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation.J Clin Endocrinol Metab. 1993; 77: 1554-1562
- Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers.Am J Obstet Gynecol. 2015; 212: 227.e1-7
- Placental glucose transporter (GLUT)-1 is down-regulated in preeclampsia.Placenta. 2017; 55: 94-99
- Intrauterine growth restriction: antenatal and postnatal aspects.Clin Med Insights Pediatr. 2016; 10: 67-83
- Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2.Clin Sci (Lond). 2016; 130: 499-512
- Changes in placental nutrient transporter protein expression and activity across gestation in normal and obese women.Reprod Sci. 2020; 27: 1758-1769
- Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction.Clin Sci (Lond). 2020; 134: 53-70
- Intrauterine growth restriction is associated with a reduced activity of placental taurine transporters.Pediatr Res. 1998; 44: 233-238
- Placental transport of leucine and lysine is reduced in intrauterine growth restriction.Pediatr Res. 1998; 44: 532-537
- Amino acid (system A) transporter activity in microvillous membrane vesicles from the placentas of appropriate and small for gestational age babies.Pediatr Res. 1993; 34: 661-665
- Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction.Pediatr Res. 1997; 42: 514-519
- Steady state maternal-fetal leucine enrichments in normal and intrauterine growth-restricted pregnancies.Pediatr Res. 1999; 46: 114-119
- Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnancies.J Clin Endocrinol Metab. 2001; 86: 5427-5432
- Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet.J Physiol. 2006; 576: 935-946
- Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon.Am J Physiol Regul Integr Comp Physiol. 2015; 309: R740-R746
- Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in maternal nutrient restricted baboons.Biol Reprod. 2016; 95: 98
- New perspectives on placental fatty acid transfer.Prostaglandins Leukot Essent Fatty Acids. 2018; 138: 24-29
- Placental fatty acid transfer.Curr Opin Clin Nutr Metab Care. 2018; 21: 78-82
- Maternal BMI and gestational diabetes alter placental lipid transporters and fatty acid composition.Placenta. 2017; 57: 144-151
- Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women.Placenta. 2016; 40: 60-66
- Triglyceride hydrolase activities and expression of fatty acid binding proteins in the human placenta in pregnancies complicated by intrauterine growth restriction and diabetes.J Clin Endocrinol Metab. 2004; 89: 4607-4614
- Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies.J Clin Endocrinol Metab. 2007; 92: 2256-2263
- Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction.Clin Sci (Lond). 2018; 132: 595-607
- The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.PLoS One. 2011; 6: e25865
- Placental fatty acid transport across late gestation in a baboon model of intrauterine growth restriction.J Physiol. 2020; 598: 2469-2489
- Maternal plasma cholesterol concentration and preterm birth: a meta-analysis and systematic review of literature.J Matern Fetal Neonatal Med. 2020; 33: 2291-2299
- Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice.Sci Rep. 2017; 7: 3982
- Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-alpha and the RFC.Sci Rep. 2016; 6: 31705
- Down-regulation of placental folate transporters in intrauterine growth restriction.J Nutr Biochem. 2018; 59: 136-141
- Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.J Extracell Vesicles. 2018; 7: 1535750
- Placenta-derived extracellular vesicles induce preeclampsia in mouse models.Haematologica. 2020; 105: 1686-1694
- Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes.FASEB J. 2020; 34: 5724-5739
- Second trimester extracellular microRNAs in maternal blood and fetal growth: an exploratory study.Epigenetics. 2017; 12: 804-810
- Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth.Placenta. 2018; 64: 34-43
- Placental exosomes: a proxy to understand pregnancy complications.Am J Reprod Immunol. 2018; 79: e12788
- Endogenous and exogenous miR-520c-3p modulates CD44-mediated extravillous trophoblast invasion.Placenta. 2017; 50: 25-31
- Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNF-alpha.Development. 2020; 147: dev187013
- Gestational diabetes mellitus is associated with changes in the concentration and bioactivity of placenta-derived exosomes in maternal circulation across gestation.Diabetes. 2016; 65: 598-609
- Trophoblast-derived exosomes mediate monocyte recruitment and differentiation.Am J Reprod Immunol. 2011; 65: 65-77
- Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis.Am J Obstet Gynecol. 2018; 218: 287-293.e1
- The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis.Am J Obstet Gynecol. 2017; 216: 110-120.e6
- Antiplatelet therapy before or after 16 weeks' gestation for preventing preeclampsia: an individual participant data meta-analysis.Am J Obstet Gynecol. 2017; 216: 121-128.e2
- Aspirin for the prevention of placenta-mediated complications in pregnant women with chronic hypertension.J Gynecol Obstet Hum Reprod. 2020; 49: 101845
- Prophylaxis and treatment of foetal growth restriction.Best Pract Res Clin Obstet Gynaecol. 2018; 49: 66-78
- Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: a meta-analysis of individual patient data from randomised controlled trials.Lancet. 2016; 388: 2629-2641
- LMWH in the prevention of preeclampsia and fetal growth restriction in women without thrombophilia. A systematic review and meta-analysis.Thromb Haemost. 2016; 116: 868-878
- Trial of Viagra for fetal growth restriction is halted after baby deaths.BMJ. 2018; 362: k3247
- Placental effects and transfer of sildenafil in healthy and preeclamptic conditions.EBioMedicine. 2019; 45: 447-455
- Safety evaluation of tadalafil treatment for fetuses with early-onset growth restriction (TADAFER): results from the phase II trial.J Clin Med. 2019; 8: 856
- Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry independent of maternal glycaemic control: a systematic review and meta-analysis.PLoS Med. 2020; 17: e1003126
- Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial.Lancet Diabetes Endocrinol. 2020; 8: 834-844
- Metformin for prevention of cesarean delivery and large-for-gestational-age newborns in non-diabetic obese pregnant women: a randomized clinical trial.Arch Endocrinol Metab. 2020; 64: 290-297
- Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: a systematic review and meta-analysis.PLoS Med. 2019; 16: e1002848
- Metformin use in obese mothers is associated with improved cardiovascular profile in the offspring.Am J Obstet Gynecol. 2020; 223: 246.e1-246.e10
- Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial.Lancet Diabetes Endocrinol. 2015; 3: 767-777
- Placental lipid droplet composition: effect of a lifestyle intervention (UPBEAT) in obese pregnant women.Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1863: 998-1005
- Docosahexaenoic acid supplementation in pregnancy modulates placental cellular signaling and nutrient transport capacity in obese women.J Clin Endocrinol Metab. 2017; 102: 4557-4567
- Uteroplacental adenovirus vascular endothelial growth factor gene therapy increases fetal growth velocity in growth-restricted sheep pregnancies.Hum Gene Ther. 2014; 25: 375-384
- EVERREST prospective study: a 6-year prospective study to define the clinical and biological characteristics of pregnancies affected by severe early onset fetal growth restriction.BMC Pregnancy Childbirth. 2017; 17: 43
- Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins.Am J Med Genet A. 2004; 131: 287-298
- Effects of pravastatin on human placenta, endothelium, and women with severe preeclampsia.Hypertension. 2015; 66 ([discussion: 445]): 687-697
- Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial.BJOG. 2020; 127: 478-488
- Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy.J Clin Invest. 2016; 126: 2933-2940
- Design of nanomaterials for applications in maternal/fetal medicine.J Mater Chem B. 2020; 8: 6548-6561
Article info
Footnotes
Funding: Supported by grants from NIH [grant numbers R01DK089989, HD089980, HD093950, HD065007, HD068370, HD078376, and T32HD007186].
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