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SUMMARY
The classes of estrogens and progestogens currently in use and their routes of administration
have been considered. The decision to prescribe any given estrogen or progestogen
and by a particular route has a significant impact on cardiovascular risk factors.
Among the estrogens, native estradiol and estrone are favored over equine and synthetic
estrogens. Given this choice, oral and systemic routes of administration are not sufficiently
different clinically to endorse one method over the other, except for the unusual
hypertensive woman or the patient with a history of thromboembolic phenomena. Among
the progestogens, oral micronized progesterone offers much promise for use in postmenopausal
women. However, the oral use of lower doses of other progestogens seems appropriate
at the present time. With the availability of oral micronized progesterone and in
time a transdermal system, the need for alternate routes of administration for other
progestogens seems unnecessary.
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© 1987 Elsevier B.V. Company. Published by Elsevier Inc. Published by Elsevier Inc. All rights reserved.
