Infertility Treatment Now and in the Future


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.


      Subscribe to Obstetrics and Gynecology Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Neto F.T.L.
        • Bach P.V.
        • Lyra R.J.L.
        • et al.
        Gods associated with male fertility and virility.
        Andrology. 2019; 7: 267-272
        • Morice P.
        • Josset P.
        • Chapron C.
        • et al.
        History of infertility.
        Hum Reprod Update. 1995; 1: 497-504
        • Smith L.
        The Kahun gynecological papyrus: ancient Egyptian medicine.
        J Fam Plann Reprod Health Care. 2011; 37: 54-55
        • Beall S.
        • Decherney A.
        The history and challenges surrounding ovarian stimulation in the treatment of infertility.
        Fertil Steril. 2012; 97: 795-801
        • Howards S.
        Antoine van Leeuwenhoek and the discovery of sperm.
        Fert Steril. 1997; 67: 16-17
        • Ombelet W.
        • Van Robays J.
        Artificial insemination history: hurdles and milestones.
        Facts Views Vis Obgyn. 2015; 7: 137-143
        • Guttmacher A.F.
        The role of artificial insemination in the treatment of human sterility.
        Bull N Y Acad Med. 1943; 19: 573-579
        • Polge C.
        • Smith A.
        • Parkes A.
        Revival of spermatozoa after vitrification and dehydration at low temperatures.
        Nature. 1949; 164: 66
        • Sztein J.M.
        • Takeo T.
        • Nakagata N.
        History of cryobiology, with special emphasis in evolution of mouse sperm cryopreservation.
        Cryobiology. 2018; 82: 57-63
        • Byrd W.
        • Ackerman G.E.
        • Carr B.R.
        • et al.
        Treatment of refractory infertility by transcervical intrauterine insemination of washed spermatatozoa.
        Fertil Steril. 1987; 48: 921-927
        • Ombelet W.
        • van Eekelen R.
        • McNally A.
        • et al.
        Should couples with unexplained infertility have three to six cycles of intrauterine insemination with ovarian stimulation or in vitro fertilization as first-line treatment.
        Fertil Steril. 2020; 114: 1141-1148
        • Gomel V.
        From laparotomy to laparoscopy to in vitro fertilization.
        Fertil Steril. 2019; 112: 183-196
        • Castellon L.A.R.
        • Amador M.I.G.
        • Gonzalez R.E.D.
        • et al.
        The history behind successful uterine transplantation in humans.
        JBRA Assist Reprod. 2017; 21: 126-134
        • Gomel V.
        Uterine transplantation.
        Climacteric. 2019; 22: 117-121
        • Olsson H.
        • Sandstrom R.
        • Grundemar L.
        Different pharmacokinetic and pharmacodynamic properties of recombinant follicle-stimulating hormone (rFSH) derived from a human cell line compared with rFSH from a non-human cell line.
        J Clin Pharmacol. 2014; 54: 1299-1307
        • Messinis I.E.
        • Nillius S.J.
        Comparison between tamoxifen and clomiphene for induction of ovulation.
        Acta Obstet Gynecol Scand. 1982; 61: 377-379
        • Mitwally M.F.
        • Biljan M.M.
        • Casper R.F.
        Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation.
        Am J Obstet Gynecol. 2005; 192: 381-386
        • Johnson M.
        Human in vitro fertilization and developmental biology: a mutually influential history.
        Development. 2019; 146: dev183145
        • Fishel S.
        First in vitro fertilization baby- this is how it happened.
        Fertil Steril. 2018; 110: 5-11
        • Eskew A.M.
        • Jungheim E.S.
        A history of developments to improve in vitro fertilization.
        Mo Med May. 2017; 114: 156-159
      1. National summary report. SART, 2018 (Available at:)
        • Chronopoulou E.
        • Harper J.C.
        IVF culture media: past, present, and future.
        Hum Reprod Update. 2015; 21: 9-55
        • De Geyter C.H.
        • Wyns C.
        • Calhaz-Jorge C.
        • et al.
        20 years of the European ivf-monitoring consortium registry: what have we learned? A comparison with registries from two other regions.
        Hum Reprod. 2020; 35: 2832-2849
        • Arav A.
        • Natan Y.
        The near future of vitrification of oocytes and embryos: looking into past experience and planning into the future.
        Transfus Med Hemother. 2019; 46: 182-186
        • Practice Committee of the American Society for Reproductive Medicine
        ASRM standard embryo transfer protocol template: a committee opinion.
        Fertil Steril. 2017; 107: 897-900
        • Takeuchi K.
        Pre-implantation genetic testing: past, present, future.
        Reprod Med Biol. 2021; 20: 27-40
        • Shitara A.
        • Takahashi K.
        • Goto M.
        • et al.
        Cell-free DNA in spent culture medium effectively reflects the chromosomal status of embryos following culturing beyond implantation compared to trophectoderm biopsy.
        PLoS One. 2021; 16: 1-13
        • Zaninovic N.
        • Rosenwaks Z.
        Artificial intelligence in human in vitro fertilization and embryology.
        Fertil Steril. 2020; 114: 914-920
        • VerMilyea M.
        • Hall J.M.M.
        • Diakiw S.M.
        • et al.
        Development of an artificial intelligence-based assessment model for prediction of embryo viability using static images captured by optical light microscopy during IVF.
        Hum Reprod. 2020; 35: 770-784
        • Hikabe O.
        • Hamazaki N.
        • Nagamatsu G.
        • et al.
        Reconstitution in vitro of the entire cycle of the mouse female germ line.
        Nature. 2016; 539: 299